Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Molecules

Zheng-Chao Tu¹  Pi-Xian Shui²  Qin Sun²  Juan Lu²  Qing Lv³  Yong-Xian Cheng³ 

[1] Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,190 Kaiyuan Road, Guangzhou 510530, China;School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China;

关键词: Catharsius molossus;    N-acetyldopamine dimers;    COX-1;    COX-2;   

DOI  :  10.3390/molecules200915589

来源: DOAJ

【 摘 要 】

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.

【 授权许可】

Unknown