Treatment Motivations and Expectations in Patients with Actinic Keratosis: A German-Wide Multicenter, Cross-Sectional Trial

Journal of Clinical Medicine

Conrad Falkenberg¹  Thomas Dirschka¹  Alexander Thiem²  Alexander Zink³  Judith Sirokay⁴  Kinan Hayani⁵  Suzan Nasifoglu⁵  Christian Krammer⁵  Enklajd Marsela⁵  Diana Lill⁵  Andreas Meiwes⁶  Ulrike Leiter⁶  Dorothée Nashan⁷  Svea Hüning⁷  Lutz Schmitz⁸  Sigrid Karrer⁹  Konstantin Drexler⁹  Katharina C. Kähler^1,10  Dagmarvon Bubnoff^1,11  Carola Berking^1,12  Anja Wessely^1,12  Theresa Steeb^1,12  Markus V. Heppt^1,12  Jessica C. Hassel^1,13  Jochen Utikal^1,14 

[1] Centroderm Clinic, 42287 Wuppertal, Germany;Clinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany;Department of Dermatology and Allergy, Technical University of Munich, 80802 Munich, Germany;Department of Dermatology and Allergy, University Hospital of Bonn, 53127 Bonn, Germany;Department of Dermatology and Allergy, University Hospital, LMU Munich, 80337 Munich, Germany;Department of Dermatology, Center for Dermatooncology, University Hospital Tübingen, 72076 Tübingen, Germany;Department of Dermatology, Hospital of Dortmund, 44137 Dortmund, Germany;Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, 44801 Bochum, Germany;Department of Dermatology, University Hospital Regensburg, 93042 Regensburg, Germany;Department of Dermatology, University Hospital Schleswig-Holstein Campus Kiel, 24105 Kiel, Germany;Department of Dermatology, University Hospital Schleswig-Holstein Campus Lübeck, 23562 Lübeck, Germany;Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany;Section of Dermatooncology, Department of Dermatology and National Center for Tumor Diseases, 69120 Heidelberg, Germany;Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167 Mannheim, Germany;

关键词: skin cancer;    patient education;    actinic keratosis;    cross-sectional study;    patient-centered care;    patient-reported outcomes;   

DOI  :  10.3390/jcm9051438

来源: DOAJ

【 摘 要 】

Patient-centered motives and expectations of the treatment of actinic keratoses (AK) have received little attention until now. Hence, we aimed to profile and cluster treatment motivations and expectations among patients with AK in a nationwide multicenter, cross-sectional study including patients from 14 German skin cancer centers. Patients were asked to complete a self-administered questionnaire. Treatment motives and expectations towards AK management were measured on a visual analogue scale from 1–10. Specific patient profiles were investigated with subgroup and correlation analysis. Overall, 403 patients were included. The highest motivation values were obtained for the items “avoid transition to invasive squamous cell carcinoma” (mean ± standard deviation; 8.98 ± 1.46), “AK are considered precancerous lesions” (8.72 ± 1.34) and “treating physician recommends treatment” (8.10 ± 2.37; p < 0.0001). The highest expectation values were observed for the items “effective lesion clearance” (8.36 ± 1.99), “safety” (8.20 ± 2.03) and “treatment-related costs are covered by health insurance” (8.00 ± 2.41; p < 0.0001). Patients aged ≥77 years and those with ≥7 lesions were identified at high risk of not undergoing any treatment due to intrinsic and extrinsic motivation deficits. Heat mapping of correlation analysis revealed four clusters with distinct motivation and expectation profiles. This study provides a patient-based heuristic tool for a personalized treatment decision in patients with AK.

【 授权许可】

Unknown