Effects of Anthocyanins on Vascular Health

Biomolecules

Constantin T. Luca¹  Ioana Mozos²  Cristina Gug³  Corina Flangea⁴  Daliborca C. Vlad⁴  Olaf K. Horbańczuk⁵  Costin Mozos⁶  Jarosław O. Horbańczuk⁷  Atanas G. Atanasov⁷  Dana Stoian⁸ 

[1]Department of Cardiology–Cardiology II, “Victor Babeş” University of Medicine and Pharmacy, 300310 Timisoara, Romania

[2]Department of Functional Sciences-Pathophysiology, Center for Translational Research and Systems Medicine, “Victor Babes” University of Medicine and Pharmacy, 300173 Timisoara, Romania

[3]Department of Microscopic Morphology-Genetics, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, Romania

[4]Department of Pharmacology and Biochemistry-Pharmacology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

[5]Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, Poland

[6]Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300042 Timisoara, Romania

[7]Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland

[8]nd Department of Internal Medicine-Endocrinology, “Victor Babeş” University of Medicine and Pharmacy, 300723 Timisoara, Romania

关键词: anthocyanins;    arterial stiffness;    endothelial function;    cardiovascular risk;    berries;    antioxidants;   

DOI  :  10.3390/biom11060811

来源: DOAJ

【 摘 要 】

Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits and vegetables has well-known health benefits, especially due to its polyphenolic components. Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. The present review aims to give a current overview of the mechanisms involved in the vascular protective effect of anthocyanins from the human diet, considering epidemiological data, in vitro and in vivo preclinical research, clinical observational, retrospective, intervention and randomized studies, dietary and biomarker studies, and discussing preventive benefits of anthocyanins and future research directions.

【 授权许可】

Unknown