Reducing Passive Drug Diffusion from Electrophoretic Drug Delivery Devices through Co‐Ion Engineering

Advanced Science

Elise P. W. Jenkins¹  George G. Malliaras¹  Shao‐Tuan Chen¹  Christopher M. Proctor¹  Megan N. Renny²  Robert R. McLeod²  Liliana C. Tomé³  David Mecerreyes³  Esther Udabe³  Jorge L. Olmedo‐Martínez³ 

[1] Electrical Engineering Division Department of Engineering University of Cambridge Cambridge CB3 0FA UK;Materials Science and Engineering Program University of Colorado Boulder CO 80309 USA;POLYMAT, University of the Basque Country UPV/EHU Avenida Tolosa 72 Donostia‐San Sebastian 20018 Gipuzkoa, Spain;

关键词: bioelectronics;    device optimization;    electrophoretic transport;    targeted drug delivery;   

DOI  :  10.1002/advs.202003995

来源: DOAJ

【 摘 要 】

Abstract Implantable electrophoretic drug delivery devices have shown promise for applications ranging from treating pathologies such as epilepsy and cancer to regulating plant physiology. Upon applying a voltage, the devices electrophoretically transport charged drug molecules across an ion‐conducting membrane out to the local implanted area. This solvent‐flow‐free “dry” delivery enables controlled drug release with minimal pressure increase at the outlet. However, a major challenge these devices face is limiting drug leakage in their idle state. Here, a method of reducing passive drug leakage through the choice of the drug co‐ion is presented. By switching acetylcholine's associated co‐ion from chloride to carboxylate co‐ions as well as sulfopropyl acrylate‐based polyanions, steady‐state drug leakage rate is reduced up to sevenfold with minimal effect on the active drug delivery rate. Numerical simulations further illustrate the potential of this method and offer guidance for new material systems to suppress passive drug leakage in electrophoretic drug delivery devices.

【 授权许可】

Unknown