Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease

Acta Pharmaceutica Sinica B

Wei Wang¹  Hongjuan Tong¹  Kaiyan Lou¹ 

[1] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China;

关键词: Alzheimer׳s disease;    Blood-brain barrier;    Fluorescence probe;    Near-infrared fluorescence;    Optical imaging;    Amyloid-β plagues;   

DOI  :  10.1016/j.apsb.2014.12.006

来源: DOAJ

【 摘 要 】

One of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.

【 授权许可】

Unknown