Review of Laboratory Methods to Determine HDL and LDL Subclasses and Their Clinical Importance

Reviews in Cardiovascular Medicine

Mehdi Hedayati¹  Abdolreza Chary² 

[1] Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 1985717413 Tehran, Iran;Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Science, Shaheed Beheshti University of Medical Sciences, 1985717413 Tehran, Iran;

关键词: laboratory assessment;    ldl;    hdl;    lipoprotein;    review;   

DOI  :  10.31083/j.rcm2304147

来源: DOAJ

【 摘 要 】

Given the high prevalence of cardiovascular disease, accurate identification of methods for assessing lipoprotein subclasses, mainly low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions, can play an essential role in predicting the incidence of cardiovascular disease such as heart attack. LDL and HDL subclasses differ in size, surface charge, lipid and protein compositions, and biological role. There is no “gold standard” method for measuring the LDL and HDL subclasses or standardizing the different methods used to measure their subfractions. Over the past decades, various techniques have been introduced to evaluate and measure subclasses of these two lipoproteins, each with its own advantages and disadvantages. Development of laboratory methods that accurately HDL and LDL function must be developed and validated to high-throughput for clinical usage. In this review study, we tried to examine different methods of evaluating various subclasses of LDL and HDL by mentioning the strengths and weaknesses of each.

【 授权许可】

Unknown