Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Applied Sciences

Muhammad Shahbaz¹  Muhammad Atif²  Tahira Batool Qaisrani³  Ghulam Hussain⁴  Natália Martins⁵  Muhammad Nadeem⁶  Rai Muhammad Amir⁷  Ali Imran⁸  Javad Sharifi-Rad⁹  Bahare Salehi^1,10  Muhammad Wasim Sajid^1,11  Miquel Martorell^1,12  Tanweer Aslam Gondal^1,13  Elise Adrian Ostrander^1,14  Muhammad Imran^1,15  William C. Cho^1,16 

[1] Home Economics, Institute of Home and Food Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan;Department of Agricultural Engineering and Technology, Ghazi University, Dera Ghazi Khan 32200, Pakistan;Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal 57000, Pakistan;Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72341, Saudi Arabia;Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China;Department of Environmental Sciences, Comsats University Islamabad, Vehari Campus, Vehari 61100, Pakistan;Department of Food Science and Technology, MNS-University of Agriculture, Multan 66000, Pakistan;;Department of Food Science, Nutrition &Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile;Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan;Institute of Food and Nutritional Sciences, PMAS-Arid Agriculture University, Rawalpindi 46300, Pakistan;Medical Illustration, Kendall College of Art and Design, Ferris State University, Grand Rapids, MI 49503, USA;School of Exercise and Nutrition, Deakin University, Victoria 3221, Australia;Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran;University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore 54000, Pakistan;Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran;

关键词: rosemary;    rosmarinic acid;    anticancer;    antidiabetic;    cardioprotective;    antioxidant;    oxidative stress;   

DOI  :  10.3390/app9153139

来源: DOAJ

【 摘 要 】

Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.

【 授权许可】

Unknown