Toxics | |
Environmentally Relevant Levels of Depleted Uranium Impacts Dermal Fibroblast Proliferation, Viability, Metabolic Activity, and Scratch Closure | |
Matthew Salanga1  Robert Kellar1  Nathan Cruz1  Robert Buscaglia2  | |
[1] Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA;Department of Mathematics and Statistics, Northern Arizona University, Flagstaff, AZ 86011, USA; | |
关键词: uranyl nitrate; skin; Navajo Nation; statistical modeling; wound healing; scratch assay; | |
DOI : 10.3390/toxics9090211 | |
来源: DOAJ |
【 摘 要 】
Uranium (U) is a heavy metal used in military and industrial settings, with a large portion being mined from the Southwest region of the United States. Uranium has uses in energy and military weaponry, but the mining process has released U into soil and surface waters that may pose threats to human and environmental health. The majority of literature regarding U’s human health concern focuses on outcomes based on unintentional ingestion or inhalation, and limited data are available about its influence via cutaneous contact. Utilizing skin dermis cells, we evaluated U’s topical chemotoxicity. Employing soluble depleted uranium (DU) in the form of uranyl nitrate (UN), we hypothesized that in vitro exposure of UN will have cytotoxic effects on primary dermal fibroblasts by affecting cell viability and metabolic activity and, further, may delay wound healing aspects via altering cell proliferation and migration. Using environmentally relevant levels of U found in water (0.1
【 授权许可】
Unknown