Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities

Molecules

Chen-Yang Li¹  Xiao-Dong Wang¹  Hong-Tao Wang²  Yan Zhu³  Miao-Miao Jiang³  Yue-Fei Wang³  Xiu-Mei Gao³  Jiang-Tao Zhou³  Chun-Hua Wang³ 

[1] Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China;Shijiazhuang Yiling Pharmaceutical Co., Ltd, Shijiazhuang 050035, China;Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;

关键词: Rhodiola crenulata;    phenol;    antioxidant activity;    IFN-γ production;    immunomodulatory effect;   

DOI  :  10.3390/molecules200813725

来源: DOAJ

【 摘 要 】

In the present study, two new phenolic compounds 1 and 11, a pair of lignan isomers 12 and 13 with their absolute configurations established for the first time, were isolated from the ethanol extract of the roots of Rhodiola crenulata, together with 13 known phenolic compounds, and their structures were elucidated via NMR, HRESIMS, UV, IR and CD analyses. All the isolated compounds were evaluated for their in vitro antioxidant activities using the 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. Ten of them exhibited significant antioxidant activities compared to ascorbic acid. Furthermore, the inducibilities of the isolated compounds to IFN-γ production were also assessed. Compounds 1, 8, 9, 12, 13, 14 and 15 could moderately stimulate IFN-γ expression.

【 授权许可】

Unknown