Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets

Biomedicines

Partap G. Bhatia¹  Koon Chu Yaiw²  Suhas Vasaikar³  Pooja Bhatia⁴ 

[1] Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto 840231, Nigeria;Experimental Cardiovascular Research Unit, Department of Medicine-Solna, Center for Molecular Medicine, Karolinska Institute, Stockholm 17177, Sweden;Integrative Biology, Baylor College of Medicine, Houston, TX 77030, USA;School of Biological Sciences, Indian Institute of Technology, Delhi 110016, India;

关键词: drug discovery;    drug design;    drug targets;    repositioning;    molecular imaging;   

DOI  :  10.3390/biomedicines4040027

来源: DOAJ

【 摘 要 】

In the past decade, it was observed that the relationship between the emerging New Molecular Entities and the quantum of R&D investment has not been favorable. There might be numerous reasons but few studies stress the introduction of target based drug discovery approach as one of the factors. Although a number of drugs have been developed with an emphasis on a single protein target, yet identification of valid target is complex. The approach focuses on an in vitro single target, which overlooks the complexity of cell and makes process of validation drug targets uncertain. Thus, it is imperative to search for alternatives rather than looking at success stories of target-based drug discovery. It would be beneficial if the drugs were developed to target multiple components. New approaches like reverse engineering and translational research need to take into account both system and target-based approach. This review evaluates the strengths and limitations of known drug discovery approaches and proposes alternative approaches for increasing efficiency against treatment.

【 授权许可】

Unknown