Region-specific slowing of alpha oscillations associated with visual-perceptual abilities in children born very preterm

Frontiers in Human Neuroscience

Alexander eMoiseev¹  Sam McLeod Doesburg²  Urs eRibary³  Ruth Eckstein Grunau⁴  Anthony T Herdman⁴ 

[1] Down Syndrome Research Foundation;Hospital for Sick Children;Simon Fraser University;University of British Columbia;

关键词: Cognition;    Magnetoencephalography;    Perception;    development;    resting state;    neural oscillation;   

DOI  :  10.3389/fnhum.2013.00791

来源: DOAJ

【 摘 要 】

Children born very preterm (≤32 weeks GA) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities.The alterations in neurophysiological development underlying these problems, however, remain poorly understood.Recent research has indicated that spontaneous alpha oscillations are slowed in children born very preterm, and that atypical alpha-mediated functional network connectivity may underlie selective developmental difficulties in visual-perceptual ability in this group.The present study provides the first source-resolved analysis of slowing of spontaneous alpha oscillations in very preterm children, indicating alterations in a distributed set of brain regions concentrated in areas of posterior parietal and inferior temporal regions associated with visual-perception, as well as prefrontal cortical regions and thalamus.We also uniquely demonstrate that slowing of alpha oscillations is associated with selective difficulties in visual-perceptual ability in very preterm children.These results indicate that region-specific slowing of alpha oscillations contribute to selective developmental difficulties prevalent in this population.

【 授权许可】

Unknown