Rho Family GTPases in Fission Yeast Cytokinesis

Communicative & Integrative Biology

Brian Hercyk¹  Maitreyi Das¹ 

[1] University of Tennessee;

关键词: gtpase;    cdc42;    rho1;    rho2;    rho3;    rho4;    rho5;    gef1;    scd1;    cytokinesis;   

DOI  :  10.1080/19420889.2019.1678453

来源: DOAJ

【 摘 要 】

During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow. In the fission yeast S. pombe, actomyosin ring constriction and septum formation are concurrent processes. While S. pombe is the primary source from which the mechanics of ring assembly and constriction stem, much less is known about the regulation of Rho GTPases that control these processes. Of the six Rho GTPases encoded in S. pombe, only Rho1, the RhoA homologue, has been shown to be essential for cytokinesis. While Rho3, Rho4, and Cdc42 have defined roles in cytokinesis, Rho2 and Rho5 play minor to no roles in this process. Here we review the roles of the Rho GTPases during cytokinesis, with a focus on their regulation, and discuss whether crosstalk between GTPases, as has been reported in other organisms, exists during cytokinesis in S. pombe.

【 授权许可】

Unknown