Memantine: procognitive and antinegative effects in mental illness (a literature review)

Nevrologiâ, Nejropsihiatriâ, Psihosomatika

P. G. Yuzbashyan¹  D. V. Romanov² 

[1] Department for Borderline Mental Pathology and Psychosomatic Disorders, Mental Health Research Center;Department of Psychiatry and Psychosomatics, N.V. Sklifosofsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia;

关键词: memantine;    glutamate;    nmda receptor;    mental disorders;    schizophrenia;    depression;    bipolar disorder;    obsessive disorder;    precognitive effect;    antinegative effect;   

DOI  :  10.14412/2074-2711-2020-3-117-122

来源: DOAJ

【 摘 要 】

According to the instruction approved in the Russian Federation, Akatinol Memantine is indicated for the treatment of all types of dementia regardless of its severity. In addition, data are being accumulated on the use of memantine in a wide range of mental disorders, including schizophrenia, bipolar affective disorder, recurrent depression, obsessive-compulsive disorder, etc.This review is devoted to the analysis of an update on adjuvant therapy with memantine for the above mental disorders. It discusses the precogni-tive and antinegative effects of the drug in schizophrenia on the basis of the data of meta-analyses and double-blind, placebo-controlled studies.

【 授权许可】

Unknown