Obstetric risks of chemotherapy during pregnancy

Гинекология

Yu E Dobrokhotova¹  E I Borovkova¹ 

[1] N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;

关键词: pregnancy;    cancer;    chemotherapy;    defects developmental;    teratogenic effect;    embryotoxicity;    metastases;    delay fetal growth;   

DOI  :  10.26442/20795696.2018.6.180064

来源: DOAJ

【 摘 要 】

During the first 4 weeks of gestation, the embryo is not yet differentiated and exposure to chemotherapy occurs the all-or-nothing principle. Most vulnerable to chemotherapy is the period from 5 to 10 weeks of pregnancy, the use of 1 cytostatic increases the risk of malformations in the hearth up to 10%, and a few - up to 25%. Prescription of therapy after 12 weeks is not associated with the risk of malformations. Development, but leads to delayed growth of the fetus and pancytopenia in newborns in 30%. Probability of a metostatic lesion the placenta and fetus is extremely low and is described primarily for hematogenous tumors. The course of treatment must be completed in 3 weeks. Before giving birth.

【 授权许可】

Unknown