Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin

Molecules

AhmedFaris Aldoghachi¹  HamadAli Hamad¹  WisamNabeel Ibrahim²  SitiAslina Hussain³  Abdullah Hagar⁴  HamidHammad Enezei⁵  Syed Mahmood⁶  Abdelkader Hassani⁷  AbdAlmonem Doolaanea⁷ 

[1] Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, Serdang 43300, Malaysia;Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Doha, Qatar;Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang 43400, Malaysia;Department of Nutrition Sciences, Faculty of Allied Health Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia;Department of Oral and Maxillofacial Surgery, Collage of Dentistry, University of Anbar, Ramadi, Iraq;Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang, Gambang 26300, Malaysia;Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia;

关键词: curcumin;    gum Arabic;    sodium alginate;    nanoparticles;    cytotoxicity;   

DOI  :  10.3390/molecules25092244

来源: DOAJ

【 摘 要 】

The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.

【 授权许可】

Unknown