Anti-oxidant, anti-inflammatory, and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin

Journal of Functional Foods

Cheng Gao¹  Xiao Wang²  Si-rui Guo²  Qing Li²  Cheng-kai Wu²  Bo-sai He³  Yan-ting Gu⁴  Ying Zhang⁴  Jia-hong Wang⁴ 

[1] Beijing Friendship Hospital, Capital Medical University, Yong'an Road 59, Xicheng District, Beijing 100050, People’s Republic of China;Department of Physiology, College of Life Science and Biopharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang 110016, People’s Republic of China;School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang 110016, People’s Republic of China;School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang 110016, People’s Republic of China;

关键词: Moringa oleifera seeds;    Diabetic nephropathy;    Inflammation;    Oxidative stress;    Fibrosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The seeds of Moringa oleifera Lam (MO) in India have various biological properties, such as anti-hyperglycemia, anti-fibrosis, and anti-oxidant. Diabetic nephropathy (DN) is one of the most serious complications in diabetes mellitus. However, the mechanism of renal protection of MO seeds in DN is unclear. In this study, the DN rat model was generated by a single streptozotocin (STZ) intraperitoneal injection, which was used to explore the renal dysfunction effects of MO seeds. Pathological examination of diabetic kidney exhibited a significant change in glomerular and tubular structures. MO seeds treatment in DN rats attenuated these changes dose-dependently. MO seeds could exert anti-inflammatory, anti-fibrosis and anti-oxidative effects by inhibiting the activation of the NF-κB and TGFβ1/Smad2/3 signaling pathways, and activating the Nrf2/HO-1 signaling pathway, finally effectively attenuate renal injury of DN. And 4000 mg/kg MO seeds have the similar level of therapeutic effect as clinical doses of metformin.

【 授权许可】

Unknown