Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for up to 10 Months after Infection

Microorganisms

SandrineVan Eeckhoudt¹  Julien Favresse²  Marc Elsen²  Christine Eucher²  Jean-Michel Dogné³  Jonathan Douxfils³  Constant Gillot³ 

[1] Department of Internal Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium;Department of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium;Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, 5000 Namur, Belgium;

关键词: COVID-19;    SARS-CoV-2;    antibody;    kinetics;    long-term;    waning effect;   

DOI  :  10.3390/microorganisms9030556

来源: DOAJ

【 摘 要 】

Several studies have described the long-term kinetics of anti-SARS-CoV-2 antibodies but long-term follow-up data, i.e., > 6 months, are still sparse. Additionally, the literature is inconsistent regarding the waning effect of the serological response. The aim of this study was to explore the temporal dynamic changes of the immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a period of 10 months. Six different analytical kits for SARS-CoV-2 antibody detection were used. Positivity rates, inter-assay agreement and kinetic models were determined. A high inter-individual and an inter-methodology variability was observed. Assays targeting total antibodies presented higher positivity rates and reached the highest positivity rates sooner compared with assays directed against IgG. The inter-assay agreement was also higher between these assays. The stratification by disease severity showed a much-elevated serological response in hospitalized versus non-hospitalized patients in all assays. In this 10-month follow-up study, serological assays showed a clinically significant difference to detect past SARS-CoV-2 infection with total antibody assays presenting the highest positivity rates. The waning effect reported in several studies should be interpreted with caution because it could depend on the assay considered.

【 授权许可】

Unknown