Marine Drugs | |
Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical | |
Maria de Fátima V. Souza1 Maria Aparecida R. Vieira1 Marcia O. M. Marques2 Emídio V. L. Cunha2 George Emmanuel C. Miranda3 Anna Cláudia A. Tomaz4 Déborah R. Pessoa4 Raquel B. S. S. Nogueira4 Margareth F. F. M. Diniz4 Aline L. Xavier4 João Carlos L. R. Pita4 Marianna V. Sobral4 Marcela L. C. Pontes4 Hilzeth L. F. Pessôa5 | |
[1] Center of R&D of Plant Genetic Resources, Agronomical Institute, CP28, Campinas 13001-970, SP, Brazil;Department of Systematics and Ecology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil;Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil;Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil; | |
关键词: Dictyotaceae; dolastane diterpene; phaeophytin; mannitol; palmitic acid; linolenic acid; cytotoxicity; genotoxicity; acute toxicity; | |
DOI : 10.3390/md15100251 | |
来源: DOAJ |
【 摘 要 】
Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical.
【 授权许可】
Unknown