Formation and Transformation Behavior of Sodium Dehydroacetate Hydrates

Molecules

Sohrab Rohani¹  Chuang Xie²  Junbo Gong²  Xia Zhang²  Qiuxiang Yin²  Baohong Hou²  Yaohui Huang²  Ying Bao² 

[1] Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada;State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, China;

关键词: sodium dehydroacetate;    monohydrate;    dihydrate;    cooling crystallization;    hollow crystal;    formation mechanism;    transformation;   

DOI  :  10.3390/molecules21040458

来源: DOAJ

【 摘 要 】

The effect of various controlling factors on the polymorphic outcome of sodium dehydroacetate crystallization was investigated in this study. Cooling crystallization experiments of sodium dehydroacetate in water were conducted at different concentrations. The results revealed that the rate of supersaturation generation played a key role in the formation of the hydrates. At a high supersaturation generation rate, a new sodium dehydroacetate dihydrate needle form was obtained; on the contrary, a sodium dehydroacetate plate monohydrate was formed at a low supersaturation generation rate. Furthermore, the characterization and transformation behavior of these two hydrated forms were investigated with the combined use of microscopy, powder X-ray diffraction (PXRD), Raman spectroscopy, Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and dynamic vapor sorption (DVS). It was found that the new needle crystals were dihydrated and hollow, and they eventually transformed into sodium dehydroacetate monohydrate. In addition, the mechanism of formation of sodium dehydroacetate hydrates was discussed, and a process growth model of hollow crystals in cooling crystallization was proposed.

【 授权许可】

Unknown