Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan

Acta Pharmaceutica Sinica B

Rama Rao Tadikonda¹  Naveen Chella²  Nalini Shastri² 

[1] Blue Birds College of Pharmacy, Hanamkonda 506001, India;National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India;

关键词: Liquisolid compact;    Valsartan;    Dissolution;    Poorly soluble drug;   

DOI  :  10.1016/j.apsb.2012.07.005

来源: DOAJ

【 摘 要 】

The aim of this study was to improve the dissolution rate of the poorly soluble drug valsartan by delivering the drug as a liquisolid compact. Liquisolid compacts were prepared using propylene glycol as solvent, Avicel PH102 as carrier, and Aerosil 200 as the coating material. The crystallinity of the newly formulated drug and the interaction between excipients was examined by X-ray powder diffraction and Fourier-transform infrared spectroscopy, respectively. The dissolution studies for the liquisolid formulation and the marketed product were carried out at different pH values. The results showed no change in the crystallinity of the drug and no interaction between excipients. The dissolution efficiency of valsartan at 15 min was increased from 4.02% for plain drug and 13.58% for marketed product to 29.47% for the liquisolid formulation. The increase in the dissolution rate was also found to be significant compared to the marketed product at lower pH values, simulating the gastric environment where valsartan is largely absorbed. The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like valsartan.

【 授权许可】

Unknown