Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1

International Journal of Molecular Sciences

Mika Murai¹  Gaku Tsuji¹  Akiko Hashimoto-Hachiya¹  Masutaka Furue²  Xianghong Yan³ 

[1] Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan;G Innovation Godo Kaisha, Kobe 658-0032, Japan;;P&

关键词: Rhodiola crenulata root extract;    aryl hydrocarbon receptor;    filaggrin;    loricrin;    involucrin;    OVOL1;   

DOI  :  10.3390/ijms19061654

来源: DOAJ

【 摘 要 】

Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis.

【 授权许可】

Unknown