Extracellular Matrix Proteins Substantiate IL-28B T allele Effect on Histological Outcome of Chronic Hepatitis C

Annals of Hepatology

Mohamed M. Omran¹  Dalia Omrang²  Sameh Saif²  Azza Farid³  Mohamed Hassany³  Mohamed A. Abdelrazek⁴  Rania Zayed⁵  Ayman Yosry⁶  Ashraf Omar⁶  Abdelfattah M. Attallah⁷  Riham El Essawey⁷ 

[1] Correspondence and reprint request:;Development Department, Biotechnology Research Center, New Damietta City, Egypt;Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt;Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Egypt;Faculty of Science, Helwan University, Cairo, Egypt;National Hepatology and Tropical Medicine Research Institute, Egypt;;Research &

关键词: Interleukin-28B;    Polymorphisms;    Chronic hepatitis C;    Fibrosis severity;    Cirrhosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction and aim. The correlation between interleukin-28B (IL-28B) polymorphisms and chronic hepatitis C (CHC) progression is debatable. Here, we aimed to evaluate the relation between IL-28B C/T genotypes and the development of cirrhotic liver. Extracellular matrix (ECM) proteins, FibroScan and model for end-stage liver disease (MELD) were used to substantiate the severity of liver disease.Material and methods. IL-28B rs12979860, liver stiffness and ECM proteins were assessed in 272 CHC patients.Results. Cirrhosis percentage increased to 10%, 52% and 96% with the increasing number of T alleles (CC, CT and TT, respectively). Also, elevated ECM proteins levels were correlated with the increasing number of T alleles. Interestingly, among cirrhotic patients, liver stiffness, MELD and ECM proteins were significantly (P < 0.0001) higher in patients with TT more than CT genotype. FibroScan, hyaluronic acid, Laminin, Collagen IV and the N-terminal pro-peptide of collagen type III have high accuracy to differentiate liver status in CC from TT genotype. Area under receiver-operating characteristic curve (95% CI) were 1.0 (1.0-1.0), 0.97 (0.961.0), 0.93 (0.85-1.0), 0.98 (0.97-1.0) and 0.93 (0.91-0.97), respectively.Conclusion. This study suggests that IL-28B T allele affects the natural course of CHC type 4 and also suggests that carriage of the IL-28B C allele protects from unfavorable clinical outcomes in CHC as coexistence of C allele with T allele reduced cirrhosis severity.

【 授权许可】

Unknown