Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

Molecules

Chunling Li¹  Jiayu Sun²  Haoxing Wu²  Hongbao Sun²  Jie Li² 

[1] Department of Neurosurgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China;Department of Radiology, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, China;

关键词: functionalized cyclobutene analogues;    concise synthesis;    tetrazine ligation;    bioorthogonal chemistry;   

DOI  :  10.3390/molecules26020276

来源: DOAJ

【 摘 要 】

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation.

【 授权许可】

Unknown