The Diagnostic and Therapeutic Potential of Galectin-3 in Cardiovascular Diseases

Biomolecules

Grażyna Sygitowicz¹  Agata Maciejak-Jastrzębska¹  Dariusz Sitkiewicz¹ 

[1] Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Warsaw, 02-097 Warsaw, Poland;

关键词: galectin-3;    cardiac fibrosis;    heart failure;    atrial fibrillation;    chronic inflammation;    MMPs;   

DOI  :  10.3390/biom12010046

来源: DOAJ

【 摘 要 】

Galectin-3 plays a prominent role in chronic inflammation and has been implicated in the development of many disease conditions, including heart disease. Galectin-3, a regulatory protein, is elevated in both acute and chronic heart failure and is involved in the inflammatory pathway after injury leading to myocardial tissue remodelling. We discussed the potential utility of galectin-3 as a diagnostic and disease severity/prognostic biomarker in different cardio/cerebrovascular diseases, such as acute ischemic stroke, acute coronary syndromes, heart failure and arrhythmogenic cardiomyopathy. Over the last decade there has been a marked increase in the understanding the role of galectin-3 in myocardial fibrosis and inflammation and as a therapeutic target for the treatment of heart failure and myocardial infarction.

【 授权许可】

Unknown