Rapidly Progressive Acute Kidney Injury Associated with Nivolumab Treatment

Case Reports in Oncology

关键词: immune checkpoint inhibitors;    nivolumab;    acute kidney injury;    acute tubular necrosis;    renal biopsy;   

DOI  :  10.1159/000505235

来源: DOAJ

【 摘 要 】

A 63-year-old man with pulmonary adenocarcinoma was treated with nivolumab. High fever developed within several hours after the first administration of nivolumab; subsequently, serum creatinine levels kept increasing daily. We diagnosed acute kidney injury (AKI) as an immune-related adverse event; the patient was initially treated with 50 mg prednisolone, and the dose was then tapered. Renal biopsy pathologically revealed tubulointerstitial inflammation with strong infiltration of only T cells that were CD3+, CD4+, and CD8+. The infiltration of CD163+ M2 macrophage was also observed. AKI within 1 week after the administration of nivolumab seems to be rare; therefore, the present case provides important findings useful in daily clinical practice.

【 授权许可】

Unknown