期刊论文详细信息
International Journal of Molecular Sciences
Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease
Sandra Barata-Antunes1  Deolinda Silva1  Ana Marote1  Bárbara Mendes-Pinheiro1  AntónioJ. Salgado1  FábioG. Teixeira1  AnaV. Domingues1  Helena Vilaça-Faria1  RuiA. Sousa2 
[1] Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal;Stemmatters, Biotecnologia e Medicina Regenerativa SA, 4805-017 Guimarães, Portugal;
关键词: Parkinson’s disease;    aging;    6-hydroxydopamine;    animal model;    neurodegeneration;   
DOI  :  10.3390/ijms21103459
来源: DOAJ
【 摘 要 】

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. The neurodegeneration leading to incapacitating motor abnormalities mainly occurs in the nigrostriatal pathway due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Several animal models have been developed not only to better understand the mechanisms underlying neurodegeneration but also to test the potential of emerging disease-modifying therapies. However, despite aging being the main risk factor for developing idiopathic PD, most of the studies do not use aged animals. Therefore, this study aimed at assessing the effect of aging in the unilateral 6-hydroxydopamine (6-OHDA)-induced animal model of PD. For this, female young adult and aged rats received a unilateral injection of 6-OHDA into the medial forebrain bundle. Subsequently, the impact of aging on 6-OHDA-induced effects on animal welfare, motor performance, and nigrostriatal integrity were assessed. The results showed that aging had a negative impact on animal welfare after surgery. Furthermore, 6-OHDA-induced impairments on skilled motor function were significantly higher in aged rats when compared with their younger counterparts. Nigrostriatal histological analysis further revealed an increased 6-OHDA-induced dopaminergic cell loss in the SNpc of aged animals when compared to young animals. Overall, our results demonstrate a higher susceptibility of aged animals to 6-OHDA toxic insult.

【 授权许可】

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