Spectral luminescent properties of bacteriochlorin and aluminum phthalocyanine nanoparticles as hydroxyapatite implant surface coating

Biomedical Photonics

V. B. Loschenov¹  V. K. Balla²  B. Kundu²  Yu. S. Maklygina³  A. S. Sharova⁴  R. Steiner⁴ 

[1] The Institute for Laser Technology in Medicine and Measurement Technique;Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute;General Physics Institute of the Russian Academy of Sciences;National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);

关键词: nanophotosensitizers;    bacteriochlorin;    aluminum phthalocyanine;    photoluminescence;    hydroxyapatite implants;    photobactericidal effect of photodynamic therapy;   

DOI  :  10.24931/2413-9432-2016-5-2-4-12

来源: DOAJ

【 摘 要 】

The development and the spectral research of unique coating as crystalline nanoparticles of IR photosensitizers were performed for the creation of hydroxyapatite implants with photobactericidal properties. It has been proved that by the interaction of nanoparticles covering implant with the polar solvent, which simulates the interaction of the implant with the biocomponents in vivo (fast proliferating and with immunocompetent cells), photosensitizers nanoparticles change the spectroscopic properties, becoming fluorescent and phototoxic. Thus, the developed coating based on crystalline photosensitizer nanoparticles with studied specific properties should have antibacterial, anti-inflammatory effect by the photodynamic treatment in the near implant area. This research opens the prospect of the local prevention of inflammatory and autoimmune reactions in the area of implantation. The results of the study suggest a promising this technology in order to create implants with photobactericidal properties.

【 授权许可】

Unknown