Base-modified nucleosides: etheno derivatives

Frontiers in Chemistry

Zofia eJahnz-Wechmann¹  Piotr Aleksy Januszczyk¹  Grzegorz Ryszard Framski¹  Jerzy eBoryski¹ 

[1] Institute of Bioorganic Chemistry, Polish Academy of Sciences;

关键词: nucleoside analogs;    Antiviral activity;    Fused heterocycles;    Ethenonucleosides;    tricyclic acyclovir;   

DOI  :  10.3389/fchem.2016.00019

来源: DOAJ

【 摘 要 】

This review presents synthesis and chemistry of nucleoside analogs, possessing an additional fused, heterocyclic ring of the etheno type, such as 1,N6-ethenoadenosine, 1,N4-ethenocytidine, 1,N2-ethenoguanosine, and other related derivatives. Formation of ethenonucleosides, in the presence of α-halocarbonyl reagents and their mechanism, stability and degradation, reactions of substitution and transglycosylation, as well as their application in the nucleoside synthesis, have been described. Some of the discussed compounds may be applied as chemotherapeutic agents in antiviral and anticancer treatment, acting as pro-nucleosides of already known, biologically active nucleoside analogs..

【 授权许可】

Unknown