Mesangiogenic Progenitor Cells Are Tissue Specific and Cannot Be Isolated From Adipose Tissue or Umbilical Cord Blood

Frontiers in Cell and Developmental Biology

Marina Montali¹  Serena Barachini¹  Gabriele Buda¹  Vittoria Carnicelli²  Paolo D. Parchi³  Nicola Piolanti³  Enrico Bonicoli³  Michelangelo Scaglione³  Gian Luca Gatti⁴  Francesca M. Panvini⁵ 

[1] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy;Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy;Plastic and Reconstructive Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;Sant’Anna School of Advanced Studies, Institute of Life Sciences, Pisa, Italy;

关键词: MPCs;    MSCs;    bone marrow;    adipose tissue;    umbilical cord blood;    tissue engineering;   

DOI  :  10.3389/fcell.2021.669381

来源: DOAJ

【 摘 要 】

Mesangiogenic progenitor cells (MPCs) have been isolated from human bone marrow (BM) mononuclear cells. They attracted particular attention for the ability to differentiate into exponentially growing mesenchymal stromal cells while retaining endothelial differentiative potential. MPC power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential and clinical value, with particular reference to musculoskeletal tissues regeneration. BM and adipose tissue represent the most promising adult multipotent cell sources for bone and cartilage repair, although discussion is still open on their respective profitability. Culture determinants, as well as tissues of origin, appeared to strongly affect the regenerative potential of cell preparations, making reliable methods for cell isolation and growth a prerequisite to obtain cell-based medicinal products. Our group had established a definite consistent protocol for MPC culture, and here, we present data showing MPCs to be tissue specific.

【 授权许可】

Unknown