Role of Fucosylation in Cancer

Chinese Journal of Lung Cancer

Kun ZHANG¹  Hong WANG¹ 

[1] Department of Lung Oncology, Affiliated Hospital of the PLA Military Academy of Medical Sciences, Beijing 100071, China;

关键词: Fucosylation;    Neoplasms;    Therapy;   

DOI  :  10.3779/j.issn.1009-3419.2016.11.07

来源: DOAJ

【 摘 要 】

Fucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides have been observed in several cancer, playing a role in proliferation, invasion, metastasis, immune escape and drug-sensitiity, especially in lung cancer. Targeting the abnormality of fucosylaion in cancer will become a new strategy. The role of fucosylation in cancer will be reviewed in this article.

【 授权许可】

Unknown