Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries

Molecules

Subhadeep Roy¹  Marvin Caruthers¹ 

[1] Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA;

关键词: DNA;    RNA;    phosphoramidites;    H-phosphonates;    boranephosphonates;    metallophosphonates;    boranealkylphosphines;   

DOI  :  10.3390/molecules181114268

来源: DOAJ

【 摘 要 】

The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.

【 授权许可】

Unknown