International Journal of Molecular Sciences | |
Structural Analysis of Mitochondrial Dynamics—From Cardiomyocytes to Osteoblasts: A Critical Review | |
Karsten Keller1  Volker H. Schmitt1  Georg Daniel Duerr2  Thaqif El Khassawna3  Steffen Pabel4  Samuel Sossalla4  Ronald Man Yeung Wong5  Markus Rupp6  Nike Walter6  Volker Alt6  Friedrich Barsch7  Daniel H. Mendelsohn8  Andreas Mamilos8  Tanja Niedermair8  Katja Schnabel8  Christoph Brochhausen8  | |
[1] Department of Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz), 55131 Mainz, Germany;Department of Cardiovascular Surgery, University Medical Center Mainz (Johannes Gutenberg-University Mainz), 55131 Mainz, Germany;Department of Experimental Trauma Surgery, Justus-Liebig-University Giessen, 35390 Giessen, Germany;Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China;Department of Trauma Surgery, University Medical Centre Regensburg, 93053 Regensburg, Germany;Institute for Exercise and Occupational Medicine, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany;Institute of Pathology, University Regensburg, 93053 Regensburg, Germany; | |
关键词: mitochondria; fission; fusion; ultrastructure; heart; bone; | |
DOI : 10.3390/ijms23094571 | |
来源: DOAJ |
【 摘 要 】
Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options.
【 授权许可】
Unknown