Augmentation index and pulse wave velocity in normotensive versus preeclamptic pregnancies: a prospective case–control study using a new oscillometric method

Annals of Medicine

Christos Anthoulakis¹  Apostolos Mamopoulos² 

[1] First Department of Obstetrics & Gynecology, “Papageorgiou" General Hospital, Aristotle University of Thessaloniki;Third Department of Obstetrics & Gynecology, Hippokration (Ippokrateio) General Hospital, Aristotle University of Thessaloniki;

关键词: cardiovascular diseases;    pre-eclampsia;    pregnancy complications;    pulse wave analysis;    vascular stiffness;   

DOI  :  10.1080/07853890.2021.2014553

来源: DOAJ

【 摘 要 】

Objectives The objective of this study was to investigate whether oscillometric AS measurements are different in pregnant women with and without preeclampsia (PE). Study design This was a prospective case–control study in singleton pregnancies that had been diagnosed with PE (n = 46) versus normotensive controls (n = 46) between 2014 and 2019. In the case group, pregnancies complicated by PE were classified as either early-onset (<34 weeks of gestation) or late-onset (≥34 weeks of gestation) PE and subgroup analysis was performed. Main outcome measures Pulse wave velocity (PWV), augmentation index (Alx), and Alx at a heart rate of 75 beats per minute (Alx-75) were measured using a brachial cuff-based automatic oscillometric device (Mobil-O-Graph 24 h PWA). Results In pregnancies complicated by PE, in comparison with normotensive pregnancies, there were significant differences in PWV (p ˂ .001), and Alx-75 (p ˂ .001). In pregnancies complicated by early-onset PE, in comparison with pregnancies complicated by late-onset PE, there were significant differences in PWV (p = .006), and Alx-75 (p = .009). There was no significant difference in Alx in either of the analyses. Conclusions PWV and Alx-75 are higher in pregnancies complicated by PE, in comparison with normotensive pregnancies, as well as in early-onset PE, in comparison with late-onset PE.Key messages Pulse wave velocity is higher in pregnancies complicated by preeclampsia. Augmentation index at a heart rate of 75 beats per minute is higher in pregnancies complicated by preeclampsia. Arterial stiffness assessment is a promising risk-stratification tool for future cardiovascular complications but further studies are required.

【 授权许可】

Unknown