Journal of Clinical Medicine | |
Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene | |
DaeRyong Kang1  TaeHwa Go1  JangYoung Kim2  JiHye Huh2  Jong-Han Lee3  Juwon Kim3  San-Hui Lee4  Sang-Baek Koh5  Seongmun Jeong6  JungRan Choi7  | |
[1] Center of Biomedical Data Science, Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju 26426, Korea;Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea;Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea;Department of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea;Department of Preventive Medicine and Institute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea;Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea;Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju 26426, Korea; | |
关键词: serum urate; menopause; hypertension; xanthine dehydrogenase; cross-sectional cohort study; | |
DOI : 10.3390/jcm8050738 | |
来源: DOAJ |
【 摘 要 】
Elevated serum urate (sUA) concentrations have been associated with an increased risk of hypertension. We aimed to examine the association of sUA concentration on the risk of hypertension in pre- and post-menopausal women and investigated the association between the polymorphism of the xanthine dehydrogenase gene and the risk of hypertension. Among 7294 women, 1415 premenopausal and 5879 postmenopausal women were recruited. Anthropometric parameters as risk factors of hypertension were identify by logistic regression models. In addition, we investigated an association between xanthine dehydrogenase gene and sUA and their combined associations on the risk of hypertension. Body mass index (BMI) and waist circumference (WC) were significantly increased in accordance to the increase of sUA levels (p < 0.001). Multivariate logistic regression analysis showed postmenopausal women with a high sUA and high BMI were 3.18 times more likely to have hypertension than in those with normal and lower sUA (Odds ratio: 3.18, 95% confidence interval: 2.54−3.96). Postmenopausal women with a high WC were 1.62 times more likely to have hypertension than in those with normal and lower sUA. Subjects with the AG genotype of rs206860 was found to be at lower risk of hypertension (odd ratio: 0.287, 95% confidence interval: 0.091−0.905, p = 0.033). This cross-sectional study indicated a high sUA is associated with a higher risk of hypertension in postmenopausal women. Further well-designed prospective studies in other populations are warranted to validate our results.
【 授权许可】
Unknown