DNA repair and damage pathways in mesothelioma development and therapy

Cancer Cell International

Ansar Karimian¹  Faezeh Malakoti²  Seyed Hadi Hossini²  Forough Alemi²  Niloufar Targhazeh²  Reza Mohammadnejad²  Bahman Yousefi²  Reza Zarezadeh²  Sahar Samemaleki³  Zatollah Asemi⁴  Erfan Abadifard⁵  Simin Younesi⁶ 

[1] Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences;Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences;Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences;School of Medicine, Tehran University of Medical Sciences;Schoole of Health and Biomedical Sciences, RMIT University;

关键词: Malignant mesothelioma;    Malignant peritoneal mesothelioma;    DNA damage repair;    Signaling pathways;    BRCA1 associated protein 1;    BAP1;   

DOI  :  10.1186/s12935-022-02597-9

来源: DOAJ

【 摘 要 】

Abstract Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis. Other important etiologies for MMe development include DNA damage, over-activation of survival signaling pathways, and failure of DNA damage response (DDR). In this review article, first, we will describe the most important signaling pathways that contribute to MMe development and their interaction with DDR. Then, the contribution of DDR failure in MMe progression will be discussed. Finally, we will review the latest MMe therapeutic strategies that target the DDR pathway.

【 授权许可】

Unknown