Salvadora persica protects libido by reducing corticosterone and elevating the testosterone levels in chronic cigarette smoke exposure rats

Saudi Journal of Biological Sciences

Ahmed Alrashed¹  Majid Alhomrani¹  Awad Othman Aljohani¹  Abdulhakeem S. Alamri²  Rakan Fahad Alamer³  Yahya Mohzari⁴  Hamdan Najib Alajami⁴  Walaa F. Alsanie⁴  Farhana Yasmin⁵  Omar Khan⁶  Syed Imam Rabbani⁷  Salman Mohammed Afroz⁷  Vasudevan Mani⁷  Sultan Sajid⁷  Syed Mohammed Basheeruddin Asdaq⁸  Abdulmajead Khalid Alanazi⁹ 

[1] Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi Arabia;Corresponding author.;Clinical Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia;Department of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia;Department of Mathematics, College of Applied Sciences, AlMaarefa University, Dariyah, 13713, Riyadh, Saudi Arabia;Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia;Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia;Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713, Riyadh, Saudi Arabia;Pharmaceutical Services Administration, Inpatient Department, Main Hospital, KFMC, Riyadh, Saudi Arabia;

关键词: Cigarette smoke;    Salvadora persica;    Libido;    Hormone levels;    Phytoconstituents;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background & Objectives: Cigarette smoke is associated with several diseased states including defects in reproductive behavior. Salvadora persica (S. persica) known as the toothbrush plant is reported to possess several pharmacological properties including antidepressants and anxiolytics. The present research was done to determine the libido-protective effect of S. persica in chronic cigarette smoke-exposed rats. Materials and Methods: The decoction of freshly dried roots of S. persica (50, 100, and 200 mg/kg, oral) was administered to the chronic-cigarette smoke-exposed adult rats. The parameters related to libido were recorded using a close-camera circuit (CCTV). Serum corticosterone and testosterone levels were estimated. Further, the phytochemical constituents were identified in the decoction. The data obtained were analyzed using one-way analysis of variance and significance was considered at p < 0.05. Results: The observation from the study revealed that cigarette smoke exposure reduces the sexual activity parameters significantly (p < 0.01), besides elevated the serum corticosterone and suppressed the testosterone levels in rats. Administration of S. persica at 200 mg/kg improved significantly (p < 0.05) the parameters related to libido. The decoction also reversed the changes in the levels of tested hormones in serum. Interpretation and Conclusion: The findings indicate that a 200 mg/kg S. persica decoction can protect libido in chronic cigarette smoke-exposed rats. The activity may be due to the presence of several phytoconstituents such as alkaloid, flavonoids and phytosterols that might produce vasodilatory effect in sex organs and enhance the synthesis of endogenous testosterone to improve libido characteristics weakened by chronic cigarette smoke exposure.

【 授权许可】

Unknown