An Alternative Hypothesis Testing Strategy for Secondary Phenotype Data in Case-Control Genetic Association Studies

Frontiers in Genetics

Christoph eLange¹  John E Hokanson²  Sharon M Lutz² 

[1] Harvard School of Public Health;University of Colorado, Anschutz Medical Campus;

关键词: Genetic association;    case-control study;    secondary phenotype;    ascertainment;    proportional odds logistic regression;   

DOI  :  10.3389/fgene.2014.00188

来源: DOAJ

【 摘 要 】

Motivated by the challenges associated with accounting for the ascertainment when analyzing secondary phenotypes that are correlated with case-control status,Lin and Zeng have proposed a method that properly reflects the case-control sampling. (Lin and Zeng, 2009)The Lin and Zeng method has the advantage of accurately estimating effect sizes forsecondary phenotypes that are normally distributed or dichotomous. This method can be computationally intensive in practiceunder the null hypothesis when the likelihood surface that needs to be maximized can be relatively flat.We propose an extension of the Lin and Zeng method for hypothesis testing that uses proportional odds logistic regression to circumvent these computational issues.Through simulation studies, we compare the power and type-1 error rate of our method to standard approaches and Lin and Zeng's approach.

【 授权许可】

Unknown