Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

Cancers

Jacqueline Nathansen¹  SebastianI. Schniewind²  Claudia Peitzsch³  Franziska Schwarz⁴  Anna Dubrovska⁴ 

[1] Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany;and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany;National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany;

关键词: head and neck squamous cell carcinoma;    HNSCC;    cancer stem cells;    therapy resistance;    biomarkers;   

DOI  :  10.3390/cancers11050616

来源: DOAJ

【 摘 要 】

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells.

【 授权许可】

Unknown