Scoping Review of Neuroimaging Studies Investigating Frailty and Frailty Components

Frontiers in Medicine

Leocadio Rodríguez-Mañas¹  Fernando Maestú²  Stefan Walter³  David López-Sanz⁴  Natalia Pasquín⁵  Raquel Bernabé⁵  Isabel Suárez-Méndez⁷ 

[1] Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain;Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States;Department of Experimental Psychology, Complutense University of Madrid (UCM), Madrid, Spain;Fundación Para la Investigación Biomédica, Getafe University Hospital, Madrid, Spain;Geriatrics Department, Getafe University Hospital, Madrid, Spain;Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology (CTB), Technical University of Madrid (UPM), Madrid, Spain;

关键词: frailty;    neuroimaging (anatomic and functional);    review;    gait speed;    grip strength;   

DOI  :  10.3389/fmed.2018.00284

来源: DOAJ

【 摘 要 】

Background: Neuroimaging techniques are a cornerstone for diagnosing and investigating cognitive decline and dementia in the elderly. In frailty research, the physical as opposed to the cognitive domain of the aging process, neuroimaging studies are less common. Here we systematically review the use of neuroimaging techniques in frailty research.Methods: We searched PUBMED for any publication reporting the association between neuroimaging markers and frailty, following Fried's original definition, as well as its determining phenotypes: gait speed, grip strength, fatigue and recent weight loss in the non-diseased population older than 65 years.Results: The search returned a total of 979 abstracts which were independently screened by 3 reviewers. In total, 17 studies met the inclusion criteria. Of these, 12 studies evaluated gait speed, 2 grip strength, and 3 frailty (2 Fried Frailty, 1 Frailty Index). An association between increased burden of white matter lesions, lower fractional anisotropy, and higher diffusivity has been associated consistently to frailty and worse performance in the different frailty components.Conclusions: White matter lesions were significantly associated to frailty and frailty components thus highlighting the potential utility of neuroimaging in unraveling the underlying mechanisms of this state. However, considering small sample size and design effects, it is not possible to completely rule out reverse causality between frailty and neuroimaging findings. More studies are needed to clarify this important clinical question.

【 授权许可】

Unknown