One-Step Method to Prepare PLLA Porous Microspheres in a High-Voltage Electrostatic Anti-Solvent Process

Materials

Li-Hui Zhu¹  Shi-Bin Wang¹  Qiao Xu¹  Ying Wang¹  Ai-Zheng Chen¹  Yu-Juan Hong¹ 

[1] College of Chemical Engineering, Huaqiao University, Xiamen 361021, China;

关键词: poly-;    ">l-lactide;    porous microspheres;    aerodynamic properties;    pulmonary drug delivery;    biosafety;   

DOI  :  10.3390/ma9050368

来源: DOAJ

【 摘 要 】

A one-step method using a high-voltage electrostatic anti-solvent process was employed to fabricate poly-l-lactide (PLLA) porous microspheres (PMs). To address the simplification and control of the preparation process, a 24 full factorial experiment was performed to optimize the operating process and analyze the effect of the factors on the morphology and aerodynamic properties of the PLLA PMs, and various characterization tests were also performed. The resulting PLLA PMs exhibited an even and porous morphology with a density less than 0.4 g/cm3, a geometric mean diameter (Dg) of 10–30 μm, an aerodynamic diameter (Da) of 1–5 μm, a fine particle fraction (FPF) of 56.3%, and a porosity of 76.2%, meeting the requirements for pulmonary drug delivery. The physicochemical characterizations reveal that no significant chemical change occurred in the PLLA during the process. An investigation of its in vitro cytotoxicity and pulmonary toxicity shows no obvious toxic response, indicating good biosafety. This study indicates that the one-step method using a high-voltage electrostatic anti-solvent process has great potential in developing an inhalable drug carrier for pulmonary drug delivery.

【 授权许可】

Unknown