Interactive Psychometrics for Autism With the Human Dynamic Clamp: Interpersonal Synchrony From Sensorimotor to Sociocognitive Domains

Frontiers in Psychiatry

Guillaume Dumas¹  Amandine Pedoux²  Anna Maruani²  Aline Lefebvre²  Richard Delorme²  Florence Baillin²  Frédérique Amsellem²  Yann Beauxis⁵  Thomas Bourgeron⁵  J. A. Scott Kelso⁶  Denis A. Engemann⁷ 

[1] CHU Sainte-Justine Centre de Recherche, Precision Psychiatry and Social Physiology Laboratory, Montreal, QC, Canada;Child and Adolescent Psychiatry Department, Robert Debré Hospital, Paris, France;Department of Psychiatry, Université de Montréal, Montreal, QC, Canada;Human Brain and Behavior Laboratory, Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL, United States;Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris, Paris, France;Intelligent Systems Research Centre, University of Ulster, Derry Londonderry, United Kingdom;Parietal Project-Team, INRIA Saclay – Île de France, Palaiseau, France;

关键词: computational psychiatry;    human-machine interface (HMI);    psychometric;    interpersonal synchrony;    autism spectrum disorder;    coordination dynamics;   

DOI  :  10.3389/fpsyt.2020.510366

来源: DOAJ

【 摘 要 】

The human dynamic clamp (HDC) is a human–machine interface designed on the basis of coordination dynamics for studying realistic social interaction under controlled and reproducible conditions. Here, we propose to probe the validity of the HDC as a psychometric instrument for quantifying social abilities in children with autism spectrum disorder (ASD) and neurotypical development. To study interpersonal synchrony with the HDC, we derived five standardized scores following a gradient from sensorimotor and motor to higher sociocognitive skills in a sample of 155 individuals (113 participants with ASD, 42 typically developing participants; aged 5 to 25 years; IQ > 70). Regression analyses were performed using normative modeling on global scores according to four subconditions (HDC behavior “cooperative/competitive,” human task “in-phase/anti-phase,” diagnosis, and age at inclusion). Children with ASD had lower scores than controls for motor skills. HDC motor coordination scores were the best candidates for stratification and diagnostic biomarkers according to exploratory analyses of hierarchical clustering and multivariate classification. Independently of phenotype, sociocognitive skills increased with developmental age while being affected by the ongoing task and HDC behavior. Weaker performance in ASD for motor skills suggests the convergent validity of the HDC for evaluating social interaction. Results provided additional evidence of a relationship between sensorimotor and sociocognitive skills. HDC may also be used as a marker of maturation of sociocognitive skills during real-time social interaction. Through its standardized and objective evaluation, the HDC not only represents a valid paradigm for the study of interpersonal synchrony but also offers a promising, clinically relevant psychometric instrument for the evaluation and stratification of sociomotor dysfunctions.

【 授权许可】

Unknown