Importance of pharmacogenetics for therapeutic use of clopidogrel

Racionalna Terapija

Rančić Nemanja¹  Simić-Dragojević Viktorija¹  Kovačević Aleksandra¹ 

[1] Military Medical Academy, Belgrade, Serbia;

关键词: clopidogrel;    resistance;    platelets;    drug-drug interactions;   

DOI  :  10.5937/racter5-3176

来源: DOAJ

【 摘 要 】

Cerebrovascular and cardiovascular diseases are the worldwide leading causes of mortality. Therefore, therapy of these diseases is of great importance. Antiplatelet therapy with clopidogrel alone and in combination with aspirin has a prominent place. The major problem in clopidogrel therapy is patients' poor response to standard protocols of treatment, followed by increased rate of repeated cardiovascular events. Main cause of the poor response to antiplatelet clopidogrel therapy is pharmacogenomic modification of cytochrome P450 as well as P-glycoprotein, responsible for absorption and bioavailability. Genetic testing is recommended for patients who respond poorly to standard antiplatelet therapy.

【 授权许可】

Unknown