CORRELATION BETWEEN INFLAMMATORY PARAMETERS AND MARKERS OF CHOLESTASIS IN PATIENTS WITH CHOLEDOCHOLITHIASIS

Acta Medica Medianae

Boris Đinđić¹  Aleksandar Nagorni²  Marija Trenkić Božinović³  Goran Damnjanović⁴  Nemanja Stepanović⁴  Dušan Sokolović⁴  Zoran Damnjanović⁵  Milan Jovanović⁵ 

[1] Clinic of Gastroenterology and Hepatology, Clinical Center Niš, Serbia;University of Niš Faculty of Medicine, Serbia;Department of Internal Medicine, Military Hospital Niš, Serbia;University of Niš Faculty of Medicine, Serbia;Vascular Surgery Clinic, Clinical Center Niš, Serbia;

关键词: cholestasis;    inflammation;    choledocholithiasis;   

DOI  :  10.5633/amm.2014.0205

来源: DOAJ

【 摘 要 】

The aim of this research was to examine the relationship between inflammatory parameters and markers of cholestasis in patients with choledocholithiasis. All subjects underwent clinical, laboratory and ultrasound examination at the Department of Internal Medicine, Military Hospital Niš, Serbia. Inflammatory parameters and biochemical markers of cholestasis were measured by standard biochemical methods. Most of cholestasis markers showed no significant correlation with inflammatory parameters in blood, except for a weak significant correlation between the number of monocytes with the activity of aspartate aminotransferase (AST) (r=0.37, p<0.05). Hyperbilirubinemia was significantly correlated with the fibrinogen values (r=0.42, p<0.05), while albumin positive values were positively associated with alanine aminotransferase (ALT) activity (r=0.5, p<0.05), and negatively with the alkaline phosphatase (AP) (r=-0.43, p<0.05). In patients with choledocholithiasis, there was a positive correlation between the number of monocytes and the activities of AST, hyperbilirubinemia, and fibrinogen, albumin and ALT, while a negative correlation between albumin and AP was present.

【 授权许可】

Unknown