Recent Advances in Chemical Biology of Mitochondria Targeting

Frontiers in Chemistry

Lin Li¹  Limin Wang¹  Shenci Lu¹  Wei Huang²  Yufei Xue³  Hua Bai⁴  Haiwei Wang⁴  Bin Fang⁴  Nicolas H. Voelcker⁴  Bo Peng⁴  Li Fu⁴ 

[1] Engineering, Northwestern Polytechnical University, Xi’an, China;Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, VIC, Australia;Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia;;Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials &School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, China;

关键词: mitochondrial;    mitochondrial dysfunction;    mitochondrial-targeting molecules;    chemical biology;    chemical probe;    nanomedicine;   

DOI  :  10.3389/fchem.2021.683220

来源: DOAJ

【 摘 要 】

Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and septicemia. Thus, the design of specific mitochondria-targeting molecules and the realization of real-time acquisition of mitochondrial activity are powerful tools in the study and treatment of mitochondria dysfunction in related diseases. Recent advances in mitochondria-targeting agents have led to several important mitochondria chemical probes that offer the opportunity for selective targeting molecules, novel biological applications and therapeutic strategies. This review details the structural and physiological functional characteristics of mitochondria, and comprehensively summarizes and classifies mitochondria-targeting agents. In addition, their pros and cons and their related chemical biological applications are discussed. Finally, the potential biomedical applications of these agents are briefly prospected.

【 授权许可】

Unknown