Alginic Acid from Padina boryana Abate Particulate Matter-Induced Inflammatory Responses in Keratinocytes and Dermal Fibroblasts

Molecules

Yong-Tae Kim¹  Tae-Ki Lee²  Lei Wang³  K.K. Asanka Sanjeewa³  ThilinaU. Jayawardena³  You-Jin Jeon³  Won-Suk Kim⁴ 

[1] Department of Food Science and Biotechnology, Kunsan National University, Gunsan 54150, Korea;Department of Hotel Cuisine & Baking, Jeonnam State University, Jeonnam 57337, Korea;Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea;Department of Pharmaceutical Engineering, Silla University, Busan 46958, Korea;

关键词: Padina boryana;    alginic acid;    particulate matter;    skin;    inflammation;    chelation;   

DOI  :  10.3390/molecules25235746

来源: DOAJ

【 摘 要 】

Particulate matter (PM) is a significant participant in air pollution and is hence an inducer of serious health issues. This study aimed to evaluate the dust protective effects of alginate from Padina boryana (PBA) via inflammatory-associated pathways to develop anti-fine dust skincare products. In between the external and internal environments, the skin is considered to be more than a physical barrier. It was observed that PM stimulates inflammation in the skin via activating NF-κB and MAPK pathways. The potential of PBA to inhibit the studied pathways were evident. The metal ion content of PM was considerably reduced by PBA and thus attributed to its chelation ability. Current research demonstrated the potential of P. boryana alginates to be implemented as a protective barrier against inflammation imposed with heavy metal and bacterial-derived endotoxin bound to the surface of the PM. Concisely, the results suggest that the bioactive components derived from the brown algae Padina boryana increased the cellular resistance to PM-stimulated inflammation-driven skin damage.

【 授权许可】

Unknown