Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets

Genes

Sean Porazinski¹  Michael Ladomery¹ 

[1] Faculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK;

关键词: Hippo pathway;    alternative splicing;    yes-associated protein;    splice-switching oligonucleotides;    gene therapy;   

DOI  :  10.3390/genes9030161

来源: DOAJ

【 摘 要 】

Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.

【 授权许可】

Unknown