Proteomics and Metabolomics for Cystic Fibrosis Research

International Journal of Molecular Sciences

Nara Liessi¹  Andrea Armirotti¹  Clarissa Braccia²  Nicoletta Pedemonte³ 

[1] Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy;D3PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy;U.O.C. Genetica Medica, IRCCS Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy;

关键词: cystic fibrosis;    proteomics;    metabolomics;    post-translational modifications;    interactomics;    biomarker discovery;   

DOI  :  10.3390/ijms21155439

来源: DOAJ

【 摘 要 】

The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery for CF diagnosis. Our work particularly focuses on CFTR post-translational modifications and their role in cellular trafficking as well as on studies that allowed the identification of CFTR molecular interactors. We also show how metabolomics is currently helping biomarker discovery in CF. The most recent advances in these fields are covered by this review, as well as some considerations on possible future scenarios for new applications.

【 授权许可】

Unknown