Key Role of the CD56lowCD16low Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells

Cancers

Cinzia Fionda¹  Elisabetta Vulpis¹  Helena Stabile¹  Angela Santoni¹  Alessandra Soriani¹  Alessandra Zingoni¹  Marco Cippitelli¹  Angela Gismondi¹  MariaTeresa Petrucci²  Elena Mariggio’²  MariaRosaria Ricciardi³ 

[1] Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy;Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, 00161 Rome, Italy;Division of Hematology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy;

关键词: natural killer cells;    multiple myeloma;    immunotherapy;    HSCT;   

DOI  :  10.3390/cancers10120473

来源: DOAJ

【 摘 要 】

Natural Killer (NK) cells play a pivotal role in the immunosurveillance of Multiple Myeloma (MM), but it is still undefined whether the NK cell functional properties underlying their protective activity against MM are confined to distinct NK cell populations. Interestingly, herein we report that the CD56^lowCD16^low NK cell subset displayed higher cytolytic activity compared to the other NK cell subsets (i.e., CD56^highCD16^+/−, CD56^lowCD16^high) against MM cells and its activity was impaired in MM patients. Decreased DNAM-1 expression levels were observed on the CD56^lowCD16^low NK cells during MM progression. Evaluating NK cell subset frequency after autologous hematopoietic stem cell transplantation, we found that CD56^lowCD16^low NK cells recovered earlier after transplantation. Overall, our data denote a key role of CD56^lowCD16^low subpopulation in the killing of MM cells and suggest that the reconstitution of CD56^lowCD16^low subpopulation after HSCT could be a useful approach of adoptive immunotherapy in the treatment of relapsed/refractory MM patients.

【 授权许可】

Unknown