Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture

Ecotoxicology and Environmental Safety

Mélodie Schmitz¹  Sébastien Ronkart²  Sébastien Baekelandt³  Christelle Robert³  Katherine Nott⁴  Patrick Kestemont⁴  Jean-Marc Porcher⁴  Stéphane Betoulle⁵  Syaghalirwa N.M. Mandiki⁵  Mahaut Beghin⁵  Erin Gillet⁵  Olivier Palluel⁶ 

[1] Corresponding author.;Centre d'Economie Rurale, Health Department, 8 Rue Point du Jour, B-6900 Marloie, Belgium;Institut national de l'environnement industriel et des risques (INERIS), URM-I-02 SEBIO, BP no. 2, 60550 Verneuil en Halatte, France;La Société wallonne des eaux, 41 Rue de la Concorde, B-4800 Verviers, Belgium;Research Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, Belgium;Université de Reims Champagne-Ardennes, Stress Environnementaux et BIOsurveillance des milieux aquatiques, Campus du Moulin de la Housse, BP 1039, 51687 Reims cedex 2, France;

关键词: Drugs;    Cocktail;    Fish;    Immunity;    Neurotoxicity;    IBR;   

DOI  :  

来源: DOAJ

【 摘 要 】

Pharmaceuticals are emerging pollutants of concern for aquatic ecosystems where they are occurring in complex mixtures. In the present study, the chronic toxicity of an environmentally relevant pharmaceutical mixture on juvenile rainbow trout (Oncorhynchus mykiss) was investigated. Five pharmaceuticals (paracetamol, carbamazepine, diclofenac, naproxen and irbesartan) were selected based on their detection frequency and concentration levels in the Meuse river (Belgium). Fish were exposed for 42 days to three different concentrations of the mixture, the median one detected in the Meuse river, 10-times and 100-times this concentration. Effects on the nervous, immune, antioxidant, and detoxification systems were evaluated throughout the exposure period and their response standardized using the Integrated Biomarker Response (IBRv2) index. IBRv2 scores increased over time in the fish exposed to the highest concentration. After 42 days, fish exposed to the highest concentration displayed significantly higher levels in lysozyme activity (p < 0.01). The mixture also caused significant changes in brain serotonin turnover (p < 0.05). In short, our results indicate that the subchronic waterborne exposure to a pharmaceutical mixture commonly occurring in freshwater ecosystems may affect the neuroendocrine and immune systems of juvenile rainbow trout.

【 授权许可】

Unknown