l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

International Journal of Environmental Research and Public Health

Li Xu¹  Zhixian Zhang¹  Ziyuan Zhao¹  Yi Guo¹  Heran Ma¹  Ran Lin¹  Yudan Ma²  Jinming Zhu³ 

[1] Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China;Sports Science Research Institute of Jilin Province, Changchun 130022, China;The China-Japan Union Hospital of Jilin University, Changchun 130033, China;

关键词: C. elegans;    ">l-Arg;    antiaging;    antioxidant;    free radical;   

DOI  :  10.3390/ijerph13100969

来源: DOAJ

【 摘 要 】

The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.

【 授权许可】

Unknown